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In Hi-C, a biotin-labeled nucleotide is incorporated at the ligation junction, enabling selective purification of chimeric DNA ligation junctions followed by deep sequencing. The compatibility of Hi-C with next generation sequencing platforms makes it possible to detect chromatin interactions on an unprecedented scale.
Hi-C is a Childhood friend of DJ Quik, and a original member of the crew Quik produced for (2nd II None, Hi-C, AMG, Suga Free, Mausberg, and Penthouse Players Clique). Hi-C is one of the first rap artists to work with The Hughes Brothers (Directors of "Menace II Society", "Dead Presidents", and a few of Hi-C’s early music videos.